Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model.
Identifieur interne : 000517 ( Main/Exploration ); précédent : 000516; suivant : 000518Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model.
Auteurs : Haruo Nishijima [Japon] ; Satoko Suzuki ; Tomoya Kon ; Yukihisa Funamizu ; Tatsuya Ueno ; Rie Haga ; Chihiro Suzuki ; Akira Arai ; Tamaki Kimura ; Chieko Suzuki ; Reiko Meguro ; Yasuo Miki ; Junko Yamada ; Keisuke Migita ; Noritaka Ichinohe ; Shinya Ueno ; Masayuki Baba ; Masahiko TomiyamaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Corpus Striatum (pathology), Dendritic Spines (pathology), Disease Models, Animal, Dyskinesia, Drug-Induced (pathology), Levodopa (pharmacology), Male, Neostriatum (pathology), Neurites (drug effects), Neurites (metabolism), Neurons (pathology), Parkinson Disease (pathology), Rats, Wistar, Synapses (drug effects), Synapses (pathology).
- MESH :
- chemical , pharmacology : Levodopa.
- drug effects : Neurites, Synapses.
- metabolism : Neurites.
- pathology : Corpus Striatum, Dendritic Spines, Dyskinesia, Drug-Induced, Neostriatum, Neurons, Parkinson Disease, Synapses.
- Animals, Disease Models, Animal, Male, Rats, Wistar.
Abstract
Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia.
DOI: 10.1002/mds.25826
PubMed: 24573720
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model.</title><author><name sortKey="Nishijima, Haruo" sort="Nishijima, Haruo" uniqKey="Nishijima H" first="Haruo" last="Nishijima">Haruo Nishijima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori</wicri:regionArea><wicri:noRegion>Aomori</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Satoko" sort="Suzuki, Satoko" uniqKey="Suzuki S" first="Satoko" last="Suzuki">Satoko Suzuki</name></author><author><name sortKey="Kon, Tomoya" sort="Kon, Tomoya" uniqKey="Kon T" first="Tomoya" last="Kon">Tomoya Kon</name></author><author><name sortKey="Funamizu, Yukihisa" sort="Funamizu, Yukihisa" uniqKey="Funamizu Y" first="Yukihisa" last="Funamizu">Yukihisa Funamizu</name></author><author><name sortKey="Ueno, Tatsuya" sort="Ueno, Tatsuya" uniqKey="Ueno T" first="Tatsuya" last="Ueno">Tatsuya Ueno</name></author><author><name sortKey="Haga, Rie" sort="Haga, Rie" uniqKey="Haga R" first="Rie" last="Haga">Rie Haga</name></author><author><name sortKey="Suzuki, Chihiro" sort="Suzuki, Chihiro" uniqKey="Suzuki C" first="Chihiro" last="Suzuki">Chihiro Suzuki</name></author><author><name sortKey="Arai, Akira" sort="Arai, Akira" uniqKey="Arai A" first="Akira" last="Arai">Akira Arai</name></author><author><name sortKey="Kimura, Tamaki" sort="Kimura, Tamaki" uniqKey="Kimura T" first="Tamaki" last="Kimura">Tamaki Kimura</name></author><author><name sortKey="Suzuki, Chieko" sort="Suzuki, Chieko" uniqKey="Suzuki C" first="Chieko" last="Suzuki">Chieko Suzuki</name></author><author><name sortKey="Meguro, Reiko" sort="Meguro, Reiko" uniqKey="Meguro R" first="Reiko" last="Meguro">Reiko Meguro</name></author><author><name sortKey="Miki, Yasuo" sort="Miki, Yasuo" uniqKey="Miki Y" first="Yasuo" last="Miki">Yasuo Miki</name></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name></author><author><name sortKey="Migita, Keisuke" sort="Migita, Keisuke" uniqKey="Migita K" first="Keisuke" last="Migita">Keisuke Migita</name></author><author><name sortKey="Ichinohe, Noritaka" sort="Ichinohe, Noritaka" uniqKey="Ichinohe N" first="Noritaka" last="Ichinohe">Noritaka Ichinohe</name></author><author><name sortKey="Ueno, Shinya" sort="Ueno, Shinya" uniqKey="Ueno S" first="Shinya" last="Ueno">Shinya Ueno</name></author><author><name sortKey="Baba, Masayuki" sort="Baba, Masayuki" uniqKey="Baba M" first="Masayuki" last="Baba">Masayuki Baba</name></author><author><name sortKey="Tomiyama, Masahiko" sort="Tomiyama, Masahiko" uniqKey="Tomiyama M" first="Masahiko" last="Tomiyama">Masahiko Tomiyama</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24573720</idno><idno type="pmid">24573720</idno><idno type="doi">10.1002/mds.25826</idno><idno type="wicri:Area/PubMed/Corpus">000573</idno><idno type="wicri:Area/PubMed/Curation">000573</idno><idno type="wicri:Area/PubMed/Checkpoint">000525</idno><idno type="wicri:Area/Ncbi/Merge">003F24</idno><idno type="wicri:Area/Ncbi/Curation">003F24</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F24</idno><idno type="wicri:Area/Main/Merge">000517</idno><idno type="wicri:Area/Main/Curation">000517</idno><idno type="wicri:Area/Main/Exploration">000517</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model.</title><author><name sortKey="Nishijima, Haruo" sort="Nishijima, Haruo" uniqKey="Nishijima H" first="Haruo" last="Nishijima">Haruo Nishijima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori</wicri:regionArea><wicri:noRegion>Aomori</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Satoko" sort="Suzuki, Satoko" uniqKey="Suzuki S" first="Satoko" last="Suzuki">Satoko Suzuki</name></author><author><name sortKey="Kon, Tomoya" sort="Kon, Tomoya" uniqKey="Kon T" first="Tomoya" last="Kon">Tomoya Kon</name></author><author><name sortKey="Funamizu, Yukihisa" sort="Funamizu, Yukihisa" uniqKey="Funamizu Y" first="Yukihisa" last="Funamizu">Yukihisa Funamizu</name></author><author><name sortKey="Ueno, Tatsuya" sort="Ueno, Tatsuya" uniqKey="Ueno T" first="Tatsuya" last="Ueno">Tatsuya Ueno</name></author><author><name sortKey="Haga, Rie" sort="Haga, Rie" uniqKey="Haga R" first="Rie" last="Haga">Rie Haga</name></author><author><name sortKey="Suzuki, Chihiro" sort="Suzuki, Chihiro" uniqKey="Suzuki C" first="Chihiro" last="Suzuki">Chihiro Suzuki</name></author><author><name sortKey="Arai, Akira" sort="Arai, Akira" uniqKey="Arai A" first="Akira" last="Arai">Akira Arai</name></author><author><name sortKey="Kimura, Tamaki" sort="Kimura, Tamaki" uniqKey="Kimura T" first="Tamaki" last="Kimura">Tamaki Kimura</name></author><author><name sortKey="Suzuki, Chieko" sort="Suzuki, Chieko" uniqKey="Suzuki C" first="Chieko" last="Suzuki">Chieko Suzuki</name></author><author><name sortKey="Meguro, Reiko" sort="Meguro, Reiko" uniqKey="Meguro R" first="Reiko" last="Meguro">Reiko Meguro</name></author><author><name sortKey="Miki, Yasuo" sort="Miki, Yasuo" uniqKey="Miki Y" first="Yasuo" last="Miki">Yasuo Miki</name></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name></author><author><name sortKey="Migita, Keisuke" sort="Migita, Keisuke" uniqKey="Migita K" first="Keisuke" last="Migita">Keisuke Migita</name></author><author><name sortKey="Ichinohe, Noritaka" sort="Ichinohe, Noritaka" uniqKey="Ichinohe N" first="Noritaka" last="Ichinohe">Noritaka Ichinohe</name></author><author><name sortKey="Ueno, Shinya" sort="Ueno, Shinya" uniqKey="Ueno S" first="Shinya" last="Ueno">Shinya Ueno</name></author><author><name sortKey="Baba, Masayuki" sort="Baba, Masayuki" uniqKey="Baba M" first="Masayuki" last="Baba">Masayuki Baba</name></author><author><name sortKey="Tomiyama, Masahiko" sort="Tomiyama, Masahiko" uniqKey="Tomiyama M" first="Masahiko" last="Tomiyama">Masahiko Tomiyama</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Corpus Striatum (pathology)</term><term>Dendritic Spines (pathology)</term><term>Disease Models, Animal</term><term>Dyskinesia, Drug-Induced (pathology)</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Neostriatum (pathology)</term><term>Neurites (drug effects)</term><term>Neurites (metabolism)</term><term>Neurons (pathology)</term><term>Parkinson Disease (pathology)</term><term>Rats, Wistar</term><term>Synapses (drug effects)</term><term>Synapses (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurites</term><term>Synapses</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurites</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Dendritic Spines</term><term>Dyskinesia, Drug-Induced</term><term>Neostriatum</term><term>Neurons</term><term>Parkinson Disease</term><term>Synapses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Arai, Akira" sort="Arai, Akira" uniqKey="Arai A" first="Akira" last="Arai">Akira Arai</name><name sortKey="Baba, Masayuki" sort="Baba, Masayuki" uniqKey="Baba M" first="Masayuki" last="Baba">Masayuki Baba</name><name sortKey="Funamizu, Yukihisa" sort="Funamizu, Yukihisa" uniqKey="Funamizu Y" first="Yukihisa" last="Funamizu">Yukihisa Funamizu</name><name sortKey="Haga, Rie" sort="Haga, Rie" uniqKey="Haga R" first="Rie" last="Haga">Rie Haga</name><name sortKey="Ichinohe, Noritaka" sort="Ichinohe, Noritaka" uniqKey="Ichinohe N" first="Noritaka" last="Ichinohe">Noritaka Ichinohe</name><name sortKey="Kimura, Tamaki" sort="Kimura, Tamaki" uniqKey="Kimura T" first="Tamaki" last="Kimura">Tamaki Kimura</name><name sortKey="Kon, Tomoya" sort="Kon, Tomoya" uniqKey="Kon T" first="Tomoya" last="Kon">Tomoya Kon</name><name sortKey="Meguro, Reiko" sort="Meguro, Reiko" uniqKey="Meguro R" first="Reiko" last="Meguro">Reiko Meguro</name><name sortKey="Migita, Keisuke" sort="Migita, Keisuke" uniqKey="Migita K" first="Keisuke" last="Migita">Keisuke Migita</name><name sortKey="Miki, Yasuo" sort="Miki, Yasuo" uniqKey="Miki Y" first="Yasuo" last="Miki">Yasuo Miki</name><name sortKey="Suzuki, Chieko" sort="Suzuki, Chieko" uniqKey="Suzuki C" first="Chieko" last="Suzuki">Chieko Suzuki</name><name sortKey="Suzuki, Chihiro" sort="Suzuki, Chihiro" uniqKey="Suzuki C" first="Chihiro" last="Suzuki">Chihiro Suzuki</name><name sortKey="Suzuki, Satoko" sort="Suzuki, Satoko" uniqKey="Suzuki S" first="Satoko" last="Suzuki">Satoko Suzuki</name><name sortKey="Tomiyama, Masahiko" sort="Tomiyama, Masahiko" uniqKey="Tomiyama M" first="Masahiko" last="Tomiyama">Masahiko Tomiyama</name><name sortKey="Ueno, Shinya" sort="Ueno, Shinya" uniqKey="Ueno S" first="Shinya" last="Ueno">Shinya Ueno</name><name sortKey="Ueno, Tatsuya" sort="Ueno, Tatsuya" uniqKey="Ueno T" first="Tatsuya" last="Ueno">Tatsuya Ueno</name><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name></noCountry><country name="Japon"><noRegion><name sortKey="Nishijima, Haruo" sort="Nishijima, Haruo" uniqKey="Nishijima H" first="Haruo" last="Nishijima">Haruo Nishijima</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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